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Phenotypes Associated with This Genotype
Genotype
MGI:4943708
Allelic
Composition		 Il27ratm1Mak/Il27ratm1Mak
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il27ratm1Mak mutation (1 available); any Il27ra mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to induced arthritis ( J:151552 )
• in an E. coli-induced arthritis model, mice exhibit longer sustained inflammation and greater bone erosion compared with wild-type mice

skeleton
increased susceptibility to induced arthritis ( J:151552 )
• in an E. coli-induced arthritis model, mice exhibit longer sustained inflammation and greater bone erosion compared with wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory