Phenotypes Associated with This Genotype

Genotype
MGI:4943557

• Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her; Lrp1^tm2Her/Lrp1^tm2Her; Tg(Tagln-cre)1Her/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal aorta elastic tissue morphology ( J:82871 )

• grossly disrupted

increased aorta wall thickness ( J:82871 )

• progressive thickening of the aorta wall with age

• thickening is primarily caused by increased smooth muscle cell proliferation

dilated aorta ( J:82871 )

• aortas are consistently distended and dilated

aortic aneurysm ( J:82871 )

abdominal aorta aneurysm ( J:82871 )

atherosclerotic lesions ( J:82871 )

• pronounced atherosclerosis is seen in the aorta

increased susceptibility to atherosclerosis ( J:82871 )

• on a high cholesterol diet

• addition of Gleevec to the diet protects against atherosclerotic lesion formation

artery occlusion ( J:82871 )

• almost complete occlusion of the mesenteric arteries

increased vascular smooth muscle cell proliferation ( J:82871 )

• increase in vascular smooth muscle cell proliferation

cellular

increased vascular smooth muscle cell proliferation ( J:82871 )

• increase in vascular smooth muscle cell proliferation

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:82871 )

N • no changes in cholesterol or triglyceride levels are detected compared to mice homozygous for Ldlr^tm1Her alone

muscle

increased vascular smooth muscle cell proliferation ( J:82871 )

• increase in vascular smooth muscle cell proliferation