Analysis Tools
vision/eye
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• severe optic nerve atrophy characterized by retinal ganglion cell axon loss and excavative remodeling of the optic nerve are seen
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• iris flattening is detected by 4 months of age
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• increased depth is seen by 4 months of age
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• lens extrusion at later stages
• in some cases the mass of fiber cells pass through the pupil into the anterior chamber of the eye
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• rupture and extrusion of fiber cell mass into the vitreous at later stages
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• develop vacuoles at later stages
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• all develop posterior cataracts by 4 weeks of age that become more severe with age
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• detected in some mice by 6 months of age
• incidence increases with age
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reproductive system
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• arrests at the round spermatid stage
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nervous system
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• severe optic nerve atrophy characterized by retinal ganglion cell axon loss and excavative remodeling of the optic nerve are seen
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immune system
