Phenotypes Associated with This Genotype

Genotype
MGI:4943264

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺; Tg(Upk2-cre)6Xrw/0
• Genetic Background: involves: 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal urinary bladder urothelium morphology ( J:164579 , J:174242 )

• mice develop hyperplastic lesions in the bladder unlike wild-type mice (J:164579)

• 100% of mutants exhibit areas of hyperproliferation in the bladder urothelium from about 3 months of age, however these lesions do not progress further when examined at 12 months of age (J:174242)

neoplasm

neoplasm ( J:164579 , J:174242 )

N • hyperproliferative lesions in the bladder do not progress to carcinoma (J:164579)

N • mutants aged up to 18 months do not develop lung tumors, skin tumors or urothelial carcinoma (J:174242)