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Phenotypes Associated with This Genotype
Genotype
MGI:4943263
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Tg(Upk2-cre)6Xrw/0
Genetic
Background		 involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (47 available)
Tg(Upk2-cre)6Xrw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal urinary bladder urothelium morphology ( J:164579 , J:234236 )
• mice develop hyperplastic lesions in the bladder unlike wild-type mice (J:164579)
• mice develop premalignant bladder lesions (J:234236)

neoplasm
neoplasm ( J:164579 )
N
• hyperproliferative lesions in the bladder do not progress to carcinoma

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory