Phenotypes Associated with This Genotype

Genotype
MGI:4943260

• Allelic Composition: Fadd^tm1Wnt/Fadd^tm1Wnt; Tg(Fadd/EGFP)#Jizh/?; Tg(Mx1-cre)1Cgn/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

thymus hypoplasia ( J:168722 )

• cellularity is reduced at 4 days after induction with poly(I:C)

• cell numbers continue to drop over a 3 month period

abnormal bone marrow cell morphology/development ( J:168722 )

• bone marrow progenitor cells with a decreased tendency to develop into macrophage and dendritic cells after induction with poly(I:C)

• progenitors have reduced in vitro colony forming ability

decreased bone marrow cell number ( J:168722 )

• cellularity of bone marrow is reduced at 4 days after induction with poly(I:C)

• cell numbers continue to drop over a 3 month period

abnormal erythrocyte morphology ( J:168722 )

• RBC volume in peripheral blood is significantly reduced up to 6 days after induction with poly(I:C)

spleen hypoplasia ( J:168722 )

• cellularity is reduced at 4 days after induction with poly(I:C) but not significantly

• cell numbers continue to drop over a 3 month period

immune system

thymus hypoplasia ( J:168722 )

• cellularity is reduced at 4 days after induction with poly(I:C)

• cell numbers continue to drop over a 3 month period

spleen hypoplasia ( J:168722 )

• cellularity is reduced at 4 days after induction with poly(I:C) but not significantly

• cell numbers continue to drop over a 3 month period

endocrine/exocrine glands

thymus hypoplasia ( J:168722 )

• cellularity is reduced at 4 days after induction with poly(I:C)

• cell numbers continue to drop over a 3 month period