Phenotypes for Cd44 Trp53 MGI:4943188 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cd44^tm1Mak/Cd44^tm1Mak Trp53^tm1Tyj/Trp53⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44^tm1Mak mutation (1 available); any Cd44 mutation (74 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (237 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased metastatic potential ( J:76201 )

• osteosarcoma on the lower back and on the skull, with significantly decreased metastasis

• incidence of ibrosarcomas, osteosarcomas, hemangiosarcomas, and histiocytic sarcomas, associated life span, and tumor weight on death are not affected

increased lymphoma incidence ( J:76201 )

• 17% have lymphoma, typical of those observed in Trp53^tm1Tyj/+ mice

• 23% have lymphomas, resembling anaplastic large cell lymphomas

• lymphoma is seen in conjunction with osteosarcoma, fibrosarcoma, and histiocytic sarcoma

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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