Phenotypes Associated with This Genotype

Genotype
MGI:4942365

• Allelic Composition: Tg(CMV-cre)1Cgn/0; Tg(Kit*D814V)1Roer/0
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:169611 )

• only about 25% of mice survive to adulthood

• surviving mice show signs of spontaneous regression of the hyperproliferative dysregulation of erythropoiesis

neonatal lethality, incomplete penetrance ( J:169611 )

• rapid lethality in about 75% of neonatal mice

digestive/alimentary system

large intestinal inflammation ( J:169611 )

• survivors develop intestinal inflammation similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn

hematopoietic system

abnormal erythropoiesis ( J:169611 )

• mice appear to die of hyperproliferative dysregulation of erythropoiesis

increased nucleated erythrocyte cell number ( J:169611 )

• dramatic dysregulation of hematopoiesis characterized by excessive numbers of nucleated cells in the peripheral blood

• increase in nucleated cells is primarily the result of a population of small blastic cells with sparse cytoplasm

increased mast cell number ( J:169611 )

• survivors develop mastocytosis similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn

abnormal erythrocyte physiology ( J:169611 )

• increase in the number of nuclear shadows in blood smears indicates the presence of cells with increased mechanical fragility

liver/biliary system

abnormal liver morphology ( J:169611 )

• most of the liver parenchyma is replaced with Ter119+ cells

immune system

large intestinal inflammation ( J:169611 )

• survivors develop intestinal inflammation similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn

increased mast cell number ( J:169611 )

• survivors develop mastocytosis similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn