Phenotypes Associated with This Genotype

Genotype
MGI:4942351

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Amhr2^tm3(cre)Bhr/Amhr2⁺
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:142150 )

N • most females lack ovarian abnormalities

increased granulosa cell tumor incidence ( J:142150 , J:222579 )

♀ • 5 of 70 females developed ovarian tumors (J:142150)

♀ • ovarian tumors are granulosa cell tumors (J:142150)

♀ • 65% of mice develop granulosa-cell type tumors in the ovary (J:222579)

♀ • however, mice do not develop ovarian or fallopian tube high grade serous carcinoma (J:222579)

abnormal pregnancy ( J:142150 )

♀ • many females fail to carry pregnancies to term

decreased litter size ( J:142150 )

• many females have small litters due to fetal death after E9.5

neoplasm

increased granulosa cell tumor incidence ( J:142150 , J:222579 )

♀ • 5 of 70 females developed ovarian tumors (J:142150)

♀ • ovarian tumors are granulosa cell tumors (J:142150)

♀ • 65% of mice develop granulosa-cell type tumors in the ovary (J:222579)

♀ • however, mice do not develop ovarian or fallopian tube high grade serous carcinoma (J:222579)

increased metastatic potential ( J:142150 )

• ganulosa cell tumors are aggressive and metastasize to the lungs

endocrine/exocrine glands

increased granulosa cell tumor incidence ( J:142150 , J:222579 )

♀ • 5 of 70 females developed ovarian tumors (J:142150)

♀ • ovarian tumors are granulosa cell tumors (J:142150)

♀ • 65% of mice develop granulosa-cell type tumors in the ovary (J:222579)

♀ • however, mice do not develop ovarian or fallopian tube high grade serous carcinoma (J:222579)