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Phenotypes Associated with This Genotype
Genotype
MGI:4941741
Allelic
Composition		 Ptentm1Hwu/Ptentm1Hwu
Tsc1tm1Djk/Tsc1tm1Djk
Tg(Gdf9-icre)5092Coo/?
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (17 available); any Pten mutation (86 available)
Tg(Gdf9-icre)5092Coo mutation (1 available)
Tsc1tm1Djk mutation (2 available); any Tsc1 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal ovarian follicle morphology ( J:155357 )
• mutants exhibit premature activation of the entire primordial follicle pool with an enhanced rate of oocyte growth and follicular development greater than in either single mutant

reproductive system
abnormal ovarian follicle morphology ( J:155357 )
• mutants exhibit premature activation of the entire primordial follicle pool with an enhanced rate of oocyte growth and follicular development greater than in either single mutant

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory