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Phenotypes Associated with This Genotype
Genotype
MGI:4941718
Allelic
Composition		 Qpcttm1.2Tbay/Qpcttm1.2Tbay
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
Genetic
Background		 B6.Cg-Qpcttm1.2Tbay Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qpcttm1.2Tbay mutation (0 available); any Qpct mutation (8 available)
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:169481 )
• at 6 months, mice exhibit a lower plaque load than Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mice

behavior/neurological
behavior/neurological phenotype ( J:169481 )
N
• spatial working memory defects observed in Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mice are rescued
• mice exhibit improved motor coordination on a beam or when suspended by a string compared with Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mice

homeostasis/metabolism
amyloid beta deposits ( J:169481 )
• at 6 months, mice exhibit a lower plaque load than Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory