Phenotypes Associated with This Genotype

Genotype
MGI:4941239

• Allelic Composition: Dpysl5^tm1Gosh/Dpysl5^tm1Gosh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal Purkinje cell dendrite morphology ( J:168982 )

• at P21 and P28, Purkinje cell body is small and the diameter of primary dendrites is thinker than in wild-type mice

decreased Purkinje cell size ( J:168982 )

• at P21 and P28, Purkinje cell body is small and the diameter of primary dendrites is thinker than in wild-type mice

• however, Purkinje cells are normal at P14

abnormal neuron physiology ( J:168982 )

• following BDNF treatment, primary cultured neurons fail to exhibit an increase in primary dendrites unlike similarly treated wild-type neurons

absent long-term depression ( J:168982 )

• following conjunctive stimulation

behavior/neurological

limb grasping ( J:168982 )

• in adult mice