Phenotypes Associated with This Genotype

Genotype
MGI:4941200

• Allelic Composition: Akt3^Nmf350/Akt3⁺
• Genetic Background: C57BL/6J-Akt3^Nmf350

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased susceptibility to pharmacologically induced seizures ( J:169028 )

• induced by PTZ treatment

abnormal seizure response to electrical stimulation ( J:169028 )

• in response to transcorneal electrical stimulation, mice exhibit generalized, tonic-clonic seizures and maximal tonic hindlimb extension seizures unlike wild-type mice

• mice exhibit lower electroconvulsive threshold to generalized seizure compared with wild-type mice

maximal tonic hindlimb extension seizures ( J:169028 )

• in response to transcorneal electrical stimulation

tonic-clonic seizures ( J:169028 )

• in response to transcorneal electrical stimulation or PTZ treatment

sporadic seizures ( J:169028 )

• after 6 months, mice exhibit spontaneous sporadic seizures unlike wild-type mice

• however, mice do not exhibit interictal epileptic EEG overnight

increased brain size ( J:169028 )

increased brain weight ( J:169028 )

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:169028 )

• induced by PTZ treatment

abnormal seizure response to electrical stimulation ( J:169028 )

• in response to transcorneal electrical stimulation, mice exhibit generalized, tonic-clonic seizures and maximal tonic hindlimb extension seizures unlike wild-type mice

• mice exhibit lower electroconvulsive threshold to generalized seizure compared with wild-type mice

maximal tonic hindlimb extension seizures ( J:169028 )

• in response to transcorneal electrical stimulation

tonic-clonic seizures ( J:169028 )

• in response to transcorneal electrical stimulation or PTZ treatment

sporadic seizures ( J:169028 )

• after 6 months, mice exhibit spontaneous sporadic seizures unlike wild-type mice

• however, mice do not exhibit interictal epileptic EEG overnight