Phenotypes Associated with This Genotype

Genotype
MGI:4940495

• Allelic Composition: Cd44^tm1Hbg/Cd44^tm1Hbg
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal osteoclast differentiation ( J:101563 )

• trend towards decreased osteoclast surface in distal femur at the age of 17 weeks

increased acute inflammation ( J:131974 )

• increased neutrophil and macrophage density in the infarcted myocardium after 24 h of reperfusion

• higher neutrophil and macrophage density after 72 h and 7 days of reperfusion

abnormal response to infection ( J:86947 )

• increased neutrophil accumulation in the lungs without compromising the control of bacterial growth

• neutrophils are prominent within alveoli and small conducting airways and bronchoalveolar lavages fluid, compared with the wild-type controls at day 20 after aerosol infection with low-dose M. tuberculosis

• lesions are more loosely organized than those from the wild-type group

• at day 30 postinfection, focal lesions begin to coalesce

• at day 65 postinfection, lesions are more severe and necrosis is greater than the wild-type

limbs/digits/tail

increased diameter of tibia ( J:101563 )

• greater proximal tibia and cortical thickness

• trend towards greater cortical area

• smaller medullary area

short tibia ( J:101563 )

• shorter tibias

integument

impaired skin barrier function ( J:108938 )

• a significant delay in barrier recovery kinetics at 1 hour after acute barrier disruption

• reduced secretion of lamellar material and delayed post-secretory dispersion of secreted lamellar material at stratum granulosum-stratum corneum (SG-SC) junction of epidermis at 1 hour after acute barrier disruption

• aberrant apical polarity of LB secretion towards the SG-SC interface

• redistributed from apical to basolateral membranes

abnormal epidermal lamellar body morphology ( J:108938 )

• reduced density of epidermal lamellar body (LB) in the cytosol of keratinocytes

thin epidermis ( J:108938 )

• thinning of the epidermis

• loss of the rete ridges

• flattening of the epidermal-dermal interface

• decreased epidermal proliferation

homeostasis/metabolism

abnormal response to cardiac infarction ( J:131974 )

• enhanced and prolonged neutrophil and macrophage infiltration in the infarct in comparison with wild-type (WT) animals

• decreased myofibroblast infiltration and reduced collagen deposition in the healing infarct

• slightly reduced percentage of apoptotic cells in comparison with WT mice after 72 h of reperfusion

• normal percentage of apoptotic cells after 24 h of reperfusion

• attenuated proliferative response in comparison to WT cardiac fibroblasts

• increased left ventricular end-diastolic volume and a trend toward lower left ventricular mass in comparison with WT animals after 7 days of reperfusion

impaired skin barrier function ( J:108938 )

• a significant delay in barrier recovery kinetics at 1 hour after acute barrier disruption

• reduced secretion of lamellar material and delayed post-secretory dispersion of secreted lamellar material at stratum granulosum-stratum corneum (SG-SC) junction of epidermis at 1 hour after acute barrier disruption

• aberrant apical polarity of LB secretion towards the SG-SC interface

• redistributed from apical to basolateral membranes

abnormal lipid level ( J:108938 )

• decreased total non-saponifiable lipid level in epidermis

decreased cholesterol level ( J:108938 )

• decreased cholesterol level in epidermis

impaired wound healing ( J:131974 )

• decreased myofibroblast infiltration and reduced collagen deposition in the healing infarct

• slightly reduced percentage of apoptotic cells in comparison with WT mice after 72 h of reperfusion

• lower myofibroblast density in the infarcted myocardium after 3 days of reperfusion

• reduced proliferative activity in the infarcted myocardium

• reduced collagen content in the infarct compared with WT mice after 7 days of reperfusion

skeleton

abnormal osteoclast differentiation ( J:101563 )

• trend towards decreased osteoclast surface in distal femur at the age of 17 weeks

increased diameter of tibia ( J:101563 )

• greater proximal tibia and cortical thickness

• trend towards greater cortical area

• smaller medullary area

short tibia ( J:101563 )

• shorter tibias

hematopoietic system

abnormal osteoclast differentiation ( J:101563 )

• trend towards decreased osteoclast surface in distal femur at the age of 17 weeks

cardiovascular system

abnormal response to cardiac infarction ( J:131974 )

• enhanced and prolonged neutrophil and macrophage infiltration in the infarct in comparison with wild-type (WT) animals

• decreased myofibroblast infiltration and reduced collagen deposition in the healing infarct

• slightly reduced percentage of apoptotic cells in comparison with WT mice after 72 h of reperfusion

• normal percentage of apoptotic cells after 24 h of reperfusion

• attenuated proliferative response in comparison to WT cardiac fibroblasts

• increased left ventricular end-diastolic volume and a trend toward lower left ventricular mass in comparison with WT animals after 7 days of reperfusion

cellular

abnormal osteoclast differentiation ( J:101563 )

• trend towards decreased osteoclast surface in distal femur at the age of 17 weeks