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Phenotypes Associated with This Genotype
Genotype
MGI:4940117
Allelic
Composition		 Ctla4tm1All/Ctla4tm1All
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraTcrb)8Rest/0
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctla4tm1All mutation (2 available); any Ctla4 mutation (49 available)
Rag1tm1Mom mutation (56 available); any Rag1 mutation (132 available)
Tg(TcraTcrb)8Rest mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:140448 )
N
• mice exhibit a normal lifespan

immune system
immune system phenotype ( J:140448 )
N
• CD8+ T cells exhibit a completely naive phenotype

pigmentation
pigmentation phenotype ( J:140448 )
N
• mice do not develop autoimmune vitiligo

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory