Phenotypes for Hand2 Isl1 MGI:4940090 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hand2^tm1Dsr/Hand2^tm2.1Dsr Isl1^tm1(cre)Tmj/Isl1⁺
Genetic Background	involves: 129 * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand2^tm1Dsr mutation (0 available); any Hand2 mutation (12 available)
Hand2^tm2.1Dsr mutation (0 available); any Hand2 mutation (12 available)
Isl1^tm1(cre)Tmj mutation (0 available); any Isl1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:169213 )

• mice die at E10.5

cardiovascular system

abnormal cardiac outflow tract development ( J:169213 )

• shortened

heart right ventricle hypoplasia ( J:169213 )

• severe

cellular

increased apoptosis ( J:169213 )

• at E9.0, mice exhibit increased apoptosis in the pharyngeal mesoderm compared with wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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