Phenotypes Associated with This Genotype

Genotype
MGI:4940020

• Allelic Composition: Kit^tm1Rosay/Kit⁺; Lep^ob/Lep^ob
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal interstitial cell of Cajal morphology ( J:168676 )

• interstitial cells of Cajal networks are disrupted during the development of diabetes unlike in Kit^tm1Rosan heterozygotes

• mice exhibit loss of interstitial cells of Cajal unlike Kit^tm1Rosan heterozygotes

growth/size/body

obese ( J:168676 )

• by 4 to 6 weeks of age

homeostasis/metabolism

hyperglycemia ( J:168676 )

• by 10 to 12 weeks of age

integument

white spotting ( J:168676 )

• mice exhibit white paws and tail unlike wild-type mice

pigmentation

white spotting ( J:168676 )

• mice exhibit white paws and tail unlike wild-type mice

cellular

abnormal interstitial cell of Cajal morphology ( J:168676 )

• interstitial cells of Cajal networks are disrupted during the development of diabetes unlike in Kit^tm1Rosan heterozygotes

• mice exhibit loss of interstitial cells of Cajal unlike Kit^tm1Rosan heterozygotes