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Phenotypes Associated with This Genotype
Genotype
MGI:4939883
Allelic
Composition
Ppargtm1.1Gonz/Ppargtm1.1Gonz
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (9 available); any Lyz2 mutation (14 available)
Ppargtm1.1Gonz mutation (0 available); any Pparg mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• increase in the number of apoptotic cells in the glomeruli
• mutants exhibit excretion of high molecular weight proteins in the urine
• mutants exhibit excretion of albumin in the urine
• females develop severe nephropathy at 4-6 months of age
• kidney hypertrophy
• increase in kidney weight due to glomerulomegaly
• nephrons exhibit coarsening and fusion of podocyte foot processes
• cell destruction in the glomeruli is indicated by the accumulation of electrolucent material in podocyte foot processes
• fusion of podocyte foot processes
• glomerular basement membrane thickening
• increase in glomerular cell number
• severe glomerular inflammation associated with increased renal macrophage infiltration
• mesangial hypercellularity
• mesangial matrix expansion
• glomerulomegaly; glomeruli are enlarged in focal regions within the kidneys

homeostasis/metabolism
• mutants exhibit excretion of high molecular weight proteins in the urine
• mutants exhibit excretion of albumin in the urine

immune system
• peritoneal macrophages exhibit defective phagocytosis resulting in impaired apoptotic cell uptake and an accumulation of apoptotic cells
• peritoneal macrophages exhibit lower phagosome content and smaller filopodia than control macrophages
• mutants exhibit a marked deposition of IgG in the mesangial matrix
• mutants exhibit a marked deposition of IgM in the mesangial matrix
• apoptotic cells in mutants cannot reduce proinflammatory response as in controls, indicating enhanced proinflammatory macrophage activation within the kidney glomeruli
• mutants develop autoantibodies against nuclear proteins, ssDNA, and dsDNA
• severe glomerular inflammation associated with increased renal macrophage infiltration

hematopoietic system
• peritoneal macrophages exhibit defective phagocytosis resulting in impaired apoptotic cell uptake and an accumulation of apoptotic cells
• peritoneal macrophages exhibit lower phagosome content and smaller filopodia than control macrophages
• mutants exhibit a marked deposition of IgG in the mesangial matrix
• mutants exhibit a marked deposition of IgM in the mesangial matrix
• apoptotic cells in mutants cannot reduce proinflammatory response as in controls, indicating enhanced proinflammatory macrophage activation within the kidney glomeruli

cellular
• increase in the number of apoptotic cells in the glomeruli
• peritoneal macrophages exhibit defective phagocytosis resulting in impaired apoptotic cell uptake and an accumulation of apoptotic cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory