Phenotypes for Tg(Tcra2D2,Tcrb2D2)1Kuch Tigit MGI:4939787 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Tigit^tm1Sdl/Tigit^tm1Sdl Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (2 available)
Tigit^tm1Sdl mutation (0 available); any Tigit mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interleukin-10 secretion ( J:168902 )

increased susceptibility to experimental autoimmune encephalomyelitis ( J:168902 )

• unlike Tg(Tcra2D2,Tcrb2D2)1Kuch mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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