Tigit^tm1Sdl
Targeted Allele Detail

Summary

• Symbol: Tigit^tm1Sdl
• Name: T cell immunoreceptor with Ig and ITIM domains; targeted mutation 1, Steven D Levin
• MGI ID: MGI:4939784
• Gene: Tigit Location: Chr16:43469230-43484509 bp, - strand Genetic Position: Chr16, 28.44 cM
• Alliance: Tigit^tm1Sdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168902
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exons 1-3 was replaced with beta-galactosidase coding sequence (inserted in-frame with the original ATG start codon), followed by a neomycin resistance gene cassette. (J:175415)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tigit Mutation: 31 strains or lines available

References

• Original: J:168902 Joller N, et al., Cutting edge: TIGIT has T cell-intrinsic inhibitory functions. J Immunol. 2011 Feb 1;186(3):1338-42
• All: 13 reference(s)