Phenotypes Associated with This Genotype

Genotype
MGI:4939482

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Rheb*)Pfw}/Gt(ROSA)26Sor^{tm1(CAG-Rheb*)Pfw}; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased brain size ( J:168571 )

increased brain weight ( J:168571 )

abnormal cerebral cortex morphology ( J:168571 )

• increase in the size of the soma of cortical neurons

thickened cerebral cortex ( J:168571 )

increased oligodendrocyte number ( J:168571 )

• increase in the number of mature oligodendrocytes at P7 but not at P14

neuron hypertrophy ( J:168571 )

• increase in the size of the soma of cortical neurons

hypermyelination ( J:168571 )

• during early postnatal stages but not at 4-6 weeks or 3 months of age