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Phenotypes Associated with This Genotype
Genotype
MGI:4939155
Allelic
Composition		 S1pr1tm1Jch/S1pr1tm1Jch
Tg(GFAP-cre)25Mes/?
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
S1pr1tm1Jch mutation (0 available); any S1pr1 mutation (29 available)
Tg(GFAP-cre)25Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:168824 )
• Experimental Autoimmune Encephalitis induced by Myelin Oligodendrocyte Glycoprotein is attenuated but otherwise similar to contrtols

nervous system
astrocytosis ( J:168824 )
• does not develop in Experimental Autoimmune Encephalitis
abnormal axon morphology ( J:168824 )
• reduced axonal damage in Experimental Autoimmune Encephalitis
demyelination ( J:168824 )
• reduced in Experimental Autoimmune Encephalitis

cellular
astrocytosis ( J:168824 )
• does not develop in Experimental Autoimmune Encephalitis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory