Phenotypes Associated with This Genotype

Genotype
MGI:4938612

• Allelic Composition: Met^tm1Cbm/Met^tm1Cbm
• Genetic Background: involves: ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal muscle precursor cell migration ( J:80685 )

• untreated mutant embryos show impaired muscle precursor migration to peripheral muscles

abnormal diaphragm morphology ( J:80685 )

• untreated mutant embryos display thin amuscular diaphragms that lack any visible striations indicative of muscle fibers

diaphragmatic hernia ( J:80685 )

• a portion of mutant embryos exposed to a combination of nitrofen and bisdiamine on E8 develop defects in the left dorsolateral area of the diaphragm , indicating that diaphragmatic hernias can be induced independent of myogenic processes

• observed hernias cover 40-70% of one side of the diaphragm

thin diaphragm muscle ( J:80685 )

• untreated mutant embryos display thin diaphragms

hypaxial muscle hypoplasia ( J:80685 )

• at E18, untreated mutant embryos display underdeveloped limb musculature due to impaired muscle precursor migration to peripheral muscles

cellular

abnormal muscle precursor cell migration ( J:80685 )

• untreated mutant embryos show impaired muscle precursor migration to peripheral muscles