Phenotypes Associated with This Genotype

Genotype
MGI:4938324

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Cxcl10^tm1Adl/Cxcl10^tm1Adl
• Genetic Background: B6.129-Cxcl10^tm1Adl Apoe^tm1Unc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:166204 )

• increased incidence of death due to ruptured abdominal aorta aneurysyms following angiotensin-II infusion compared to mutant mice wild-type for Cxcl10

cardiovascular system

decreased susceptibility to atherosclerosis ( J:166204 )

• decrease in lesion size in the angiotensin-II induced model compared to mutant mice wild-type for Cxcl10

abnormal aorta morphology ( J:166204 )

• display more severe morphological changes following angiotensin-II infusion compared to mutant mice wild-type for Cxcl10

dilated aorta ( J:166204 )

• increase in the suprarenal aortic diameter and suprarenal/thoracic to infrarenal aortic area ratios in mice infused with angiotensin-II compared to mutant mice wild-type for Cxcl10

aortic aneurysm ( J:166204 )

• large aortic aneurysms with spiral dissections are seen following angiotensin-II infusion

• decrease in CD4+ T cell accumulation in angiotensin-II induced aneurysms

thoracic aorta aneurysm ( J:166204 )

• seen following angiotensin-II infusion

increased susceptibility to induced aneurysm formation ( J:166204 )

• increased incidence of death due to ruptured abdominal aorta aneurysyms following angiotensin-II infusion compared to mutant mice wild-type for Cxcl10

• large aortic aneurysms with spiral dissections are seen following angiotensin-II infusion

• increase in the incidence of grade III aneurysms following angiotensin-II infusion compared to mutant mice wild-type for Cxcl10

hematoma ( J:166204 )

• seen following angiotensin-II infusion

immune system

impaired macrophage chemotaxis ( J:166204 )

• decrease in macrophage accumulation in the arterial wall in angiotensin-II treated mice

decreased CD4-positive, alpha-beta T cell number ( J:166204 )

• decrease in CD4+ T cell accumulation in angiotensin-II induced aneurysms

hematopoietic system

impaired macrophage chemotaxis ( J:166204 )

• decrease in macrophage accumulation in the arterial wall in angiotensin-II treated mice

decreased CD4-positive, alpha-beta T cell number ( J:166204 )

• decrease in CD4+ T cell accumulation in angiotensin-II induced aneurysms

cellular

impaired macrophage chemotaxis ( J:166204 )

• decrease in macrophage accumulation in the arterial wall in angiotensin-II treated mice