Phenotypes Associated with This Genotype

Genotype
MGI:4938323

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Ifng^tm1Ts/Ifng^tm1Ts
• Genetic Background: B6.129-Apoe^tm1Unc Ifng^tm1Ts

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:166204 )

• about 50% of mice infused with angiotensin-II die within 2 to 10 days due to rupture of the abdominal aorta compared to 0 deaths of mutant mice wild-type for Ifng

cardiovascular system

dilated aorta ( J:166204 )

• increase in the suprarenal aortic diameter in mice infused with 500 ng/kg/min angiotensin-II compared to mutant mice wild-type for Ifng

increased susceptibility to induced aneurysm formation ( J:166204 )

• about 50% of mice infused with 1000 ng/kg/min angiotensin-II die within 2 to 10 days due to rupture of the abdominal aorta compared to 0 deaths of mutant mice wild-type for Ifng

• increase in the incidence of abdominal aorta aneurysyms in in mice infused with 500 ng/kg/min angiotensin-II compared to mutant mice wild-type for Ifng

growth/size/body

increased body weight ( J:166204 )

• compared to mutant mice wild-type for Ifng