Phenotypes Associated with This Genotype

Genotype
MGI:4936829

• Allelic Composition: Gli2^tm1Alj/Gli2^tm1Alj; Gli3^Xt/Gli3^Xt
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:49603 )

• most double homozygous mutants die at ~E10.5

• a small number of double homozygous mutants survive to E13.5-E14.5

respiratory system

abnormal lung development ( J:49603 )

• no lung primordia are detected at E9.5 or later

absent lungs ( J:49603 )

• all double homozygous mutant mice lack lungs

abnormal trachea development ( J:49603 )

• no tracheal primordia are detected at E9.5 or later

absent trachea ( J:49603 )

• all double homozygous mutant mice lack a trachea

digestive/alimentary system

abnormal esophagus development ( J:49603 )

• no esophageal primordia are detected at E9.5 or later

abnormal foregut morphology ( J:49603 )

• no foregut differentiation into esophagus, trachea and lung is noted at E10.5

• at E10.5, the double mutant foregut endoderm remains a single tube, except for the stomach region

absent esophagus ( J:49603 )

• all double homozygous mutant mice lack an esophagus

embryo

abnormal endoderm development ( J:49603 )

• the foregut endoderm fails to develop into lung, trachea and esophagus

• however, hepatic and pancreatic buds are present