Phenotypes for Akt2 Lep MGI:4889117 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Lep^ob/Lep^ob
Genetic Background	B6.Cg-Lep^ob Akt2^tm1.1Mbb

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1.1Mbb mutation (2 available); any Akt2 mutation (51 available)
Lep^ob mutation (5 available); any Lep mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:155432 )

• in fasted mice compared with Lep^ob homozygotes

increased circulating insulin level ( J:155432 )

• in fasted mice compared with Lep^ob homozygotes

abnormal lipid homeostasis ( J:155432 )

• mice exhibit reduced lipogenesis compared to in Lep^ob homozygotes

decreased circulating cholesterol level ( J:155432 )

• modest

decreased liver triglyceride level ( J:155432 )

• compared with Lep^ob homozygotes

growth/size/body

decreased body weight ( J:155432 )

• compared with Lep^ob homozygotes

liver/biliary system

decreased liver triglyceride level ( J:155432 )

• compared with Lep^ob homozygotes

decreased liver weight ( J:155432 )

• compared with Lep^ob homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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