Phenotypes Associated with This Genotype

Genotype
MGI:4889117

• Allelic Composition: Akt2^tm1.1Mbb/Akt2^tm1.1Mbb; Lep^ob/Lep^ob
• Genetic Background: B6.Cg-Lep^ob Akt2^tm1.1Mbb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:155432 )

• in fasted mice compared with Lep^ob homozygotes

increased circulating insulin level ( J:155432 )

• in fasted mice compared with Lep^ob homozygotes

abnormal lipid homeostasis ( J:155432 )

• mice exhibit reduced lipogenesis compared to in Lep^ob homozygotes

decreased circulating cholesterol level ( J:155432 )

• modest

decreased liver triglyceride level ( J:155432 )

• compared with Lep^ob homozygotes

growth/size/body

decreased body weight ( J:155432 )

• compared with Lep^ob homozygotes

liver/biliary system

decreased liver triglyceride level ( J:155432 )

• compared with Lep^ob homozygotes

decreased liver weight ( J:155432 )

• compared with Lep^ob homozygotes