Phenotypes Associated with This Genotype

Genotype
MGI:4889115

• Allelic Composition: Akt2^tm1.2Mbb/Akt2^tm1.2Mbb; Lep^ob/Lep^ob; Tg(Alb1-cre)1Khk/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:155432 )

• fasted mice exhibit increased plasma glucose levels compared with Akt2^tm1Mbb Lep^ob homozygotes

abnormal lipid homeostasis ( J:155432 )

• mice exhibit reduced lipogenesis compared to in Akt2^tm1Mbb Lep^ob homozygotes

decreased liver triglyceride level ( J:155432 )

• mice exhibit decreased liver triglyceride levels compared with Akt2^tm1Mbb Lep^ob homozygotes

growth/size/body

decreased body weight ( J:155432 )

• mice exhibit decreased body weight compared with Akt2^tm1Mbb Lep^ob homozygotes

• however, body composition was normal

liver/biliary system

decreased liver triglyceride level ( J:155432 )

• mice exhibit decreased liver triglyceride levels compared with Akt2^tm1Mbb Lep^ob homozygotes

decreased liver weight ( J:155432 )

• mice exhibit decreased liver weight compared with Akt2^tm1Mbb Lep^ob homozygotes