Phenotypes Associated with This Genotype

Genotype
MGI:4889078

• Allelic Composition: Hspa5^baffled/Hspa5^baffled; Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
• Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:168258 )

• mutants collected after birth died within hours (100%; 15 of 15)

nervous system

abnormal axon extension ( J:168258 )

• the thalamocortical axons are disorganized in the ventral telencephalon with some stalled at the corticostriatal boundary unlike in wild-type mice

abnormal axon fasciculation ( J:168258 )

• some thalamocortical axons are overfasciculated and stalling compared to in wild-type mice

abnormal telencephalon morphology ( J:168258 )

• the thalamocortical axons are disorganized in the ventral telencephalon with some stalled at the corticostriatal boundary unlike in wild-type mice

abnormal cortical intermediate zone morphology ( J:168258 )

• the intermediate zone contains large swollen bundles of axon compared with wild-type mice

abnormal hippocampus morphology ( J:168258 )

• round

abnormal cerebral cortex morphology ( J:168258 )

• slightly small

small olfactory bulb ( J:168258 )

• slightly small

renal/urinary system

small kidney ( J:168258 )

respiratory system

respiratory distress ( J:168258 )

cardiovascular system

hematoma ( J:168258 )

• under the nose in 20 of 21 mice

craniofacial

cleft palate ( J:168258 )

digestive/alimentary system

cleft palate ( J:168258 )

cellular

abnormal axon extension ( J:168258 )

• the thalamocortical axons are disorganized in the ventral telencephalon with some stalled at the corticostriatal boundary unlike in wild-type mice

abnormal axon fasciculation ( J:168258 )

• some thalamocortical axons are overfasciculated and stalling compared to in wild-type mice

growth/size/body

cleft palate ( J:168258 )