Analysis Tools
homeostasis/metabolism
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• females with reduced triacyl glycerol on a high fat diet
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• females with higher cholesterol levels on a normal fat diet
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cardiovascular system
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• 76% reduction in atherosclerotic lesions in the aorta when on a high fat diet as compared to Apoetm1Unc
• area covered by lesions is 5% as compared to 30% in Apoetm1Unc homozygous males
• lesions 45% smaller in size in males and mostly restricted to the aortic arch rather than throughout the aortic tree
• female lesions closer in size to Apoetm1Unc controls
• smaller lesions on a low fat diet as well and also for females
• lesions composed of more densely packed lipid laden foam cells
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growth/size/body
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• gain significantly more weight on a high fat diet than Apoetm1Unc controls
• on a normal diet only males are significantly heavier than controls
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immune system
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• less foam cell development
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• considerably less modified LDL is bound and cellular uptake is reduced
• native LDL binding is normal
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cellular
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• less foam cell development
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hematopoietic system
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• less foam cell development
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• considerably less modified LDL is bound and cellular uptake is reduced
• native LDL binding is normal
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