Phenotypes Associated with This Genotype

Genotype
MGI:4888253

• Allelic Composition: Cd36^tm1Mfe/Cd36^tm1Mfe
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:220343 )

N • fasted mice at room temperature and exposed to cold exhibit normal serum levels of non-esterified fatty acids and ketone bodies

impaired adaptive thermogenesis ( J:220343 )

• fasted mice exposed to cold exhibit a rapid drop in body temperature compared with wild-type mice

• however, fed mice exhibit normal body temperature when cold exposed

decreased circulating glucose level ( J:220343 )

• in fasted mice at room temperature and exposed to cold

decreased skeletal muscle glycogen level ( J:220343 )

• in fasted mice at room temperature and more pronounced when mice are exposed to cold

abnormal triglyceride level ( J:220343 )

• reduced triglyceride levels in brown adipose tissue in fasted mice at room temperature and more pronounced when mice are exposed to cold

decreased circulating triglyceride level ( J:220343 )

• in fasted mice at room temperature and more so in fasted mice exposed to cold

adipose tissue

decreased brown adipose tissue amount ( J:220343 )

• in fasted mice at room temperature and exposed to cold

decreased adipocyte glucose uptake ( J:220343 )

• reduced glucose uptake in the brown adipose tissue of fasted mice exposed to cold

abnormal brown adipose tissue physiology ( J:220343 )

• reduced glucose uptake in the brown adipose tissue of fasted mice exposed to cold

• reduced fatty acid uptake in the brown adipose tissue of fasted mice at room temperature and exposed to cold

nervous system

abnormal myelination ( J:89664 )

• more thinly myelinated fibers are found at 3 and 6 weeks after sciatic nerve crush injury than in controls

• myelinated fibers with decreased diameters

abnormal peripheral nervous system regeneration ( J:89664 )

• more thinly myelinated fibers are found at 3 and 6 weeks after sciatic nerve crush injury than in controls

• myelinated fibers with decreased diameters

• more macrophage present

immune system

abnormal macrophage chemotaxis ( J:89664 )

• more macrophage present at 3 and 6 weeks after sciatic nerve crush injury than in controls

muscle

decreased skeletal muscle glycogen level ( J:220343 )

• in fasted mice at room temperature and more pronounced when mice are exposed to cold

abnormal muscle physiology ( J:220343 )

• glucose uptake in skeletal muscles is not enhanced by cold-exposure in fasted mice

• reduced fatty acid uptake in skeletal muscles at room temperature and in cold-exposed fasted mice

decreased skeletal muscle cell glucose uptake ( J:220343 )

• glucose uptake in skeletal muscles is not enhanced by cold-exposure in fasted mice

cardiovascular system

abnormal blood pressure regulation ( J:109739 )

• resting coronary resistance is lower than in controls

• hexarelin fails to induce a dose dependent increase in coronary perfusion pressure as it does in controls

cellular

decreased adipocyte glucose uptake ( J:220343 )

• reduced glucose uptake in the brown adipose tissue of fasted mice exposed to cold

abnormal macrophage chemotaxis ( J:89664 )

• more macrophage present at 3 and 6 weeks after sciatic nerve crush injury than in controls

decreased skeletal muscle cell glucose uptake ( J:220343 )

• glucose uptake in skeletal muscles is not enhanced by cold-exposure in fasted mice

hematopoietic system

abnormal macrophage chemotaxis ( J:89664 )

• more macrophage present at 3 and 6 weeks after sciatic nerve crush injury than in controls