Phenotypes Associated with This Genotype

Genotype
MGI:4887973

• Allelic Composition: Runx2^tm1Mjo/Runx2⁺; Tg(Eno2tTA)#Nes/0; Tg(tetO-Zfp521)#Rbar/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal fontanelle morphology ( J:167992 )

• at P25, mice exhibit a defined nonmineralization area between the anterior and posterior fontanelles compared to in wild-type mice that is larger than in Runx2^tm1Mjo heterozygotes

abnormal hyoid bone morphology ( J:167992 )

• the midportion of the hyoid bone fails to mineralize unlike in wild-type mice

clavicle hypoplasia ( J:167992 )

• to a greater extent than in Runx2^tm1Mjo heterozygotes

craniofacial

abnormal fontanelle morphology ( J:167992 )

• at P25, mice exhibit a defined nonmineralization area between the anterior and posterior fontanelles compared to in wild-type mice that is larger than in Runx2^tm1Mjo heterozygotes

abnormal hyoid bone morphology ( J:167992 )

• the midportion of the hyoid bone fails to mineralize unlike in wild-type mice