Phenotypes Associated with This Genotype

Genotype
MGI:4887407

• Allelic Composition: Rr161^tm2.2Wtg/Rr161^tm2.2Wtg
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:167472 )

abnormal immunoglobulin V(D)J recombination ( J:167472 )

• gene rearrangement at the Igkappa locus is reduced compared to in wild-type mice and Igk^tm1.1Fwa and Igk^tm1Wtg homozygotes

decreased pro-B cell number ( J:167472 )

decreased B cell number ( J:167472 )

increased pre-B cell number ( J:167472 )

cellular

abnormal DNA methylation ( J:167472 )

hematopoietic system

abnormal B cell differentiation ( J:167472 )

abnormal immunoglobulin V(D)J recombination ( J:167472 )

• gene rearrangement at the Igkappa locus is reduced compared to in wild-type mice and Igk^tm1.1Fwa and Igk^tm1Wtg homozygotes

decreased pro-B cell number ( J:167472 )

decreased B cell number ( J:167472 )

increased pre-B cell number ( J:167472 )