Rr161^tm2.2Wtg
Targeted Allele Detail

Summary

• Symbol: Rr161^tm2.2Wtg
• Name: regulatory region 161; targeted mutation 2.2, William Garrard
• MGI ID: MGI:4887406
• Synonyms: Igk^tm2.2Wtg
• Gene: Rr161 Location: unknown Genetic Position: Chr6, Syntenic
• Alliance: Rr161^tm2.2Wtg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167472
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A loxP site was inserted upstream of 3' enhancer (E3' or Rr159), and a floxed neo cassette was inserted downstream of the E3'. An FRT site was inserted upstream of the downstream enhancer (Ed or Rr160), and an FRT-flanked puro cassette was inserted downstream of the Ed. Cre-mediated recombination removed the E3' and flp-mediated recombination removed the Ed. (J:167472)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr161 Mutation: 0 strains or lines available

References

• Original: J:167472 Zhou X, et al., The Igkappa gene enhancers, E3' and Ed, are essential for triggering transcription. J Immunol. 2010 Dec 15;185(12):7544-52
• All: 1 reference(s)