Phenotypes Associated with This Genotype

Genotype
MGI:4887353

• Allelic Composition: Ddah1^tm1Yjch/Ddah1^tm1Yjch; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal amino acid level ( J:168130 )

• increased levels of asymmetric dimethyl arginine in lung, liver, and kidney

• symmetric dimethyl arginine is elevated by about 60% only in lung

abnormal circulating amino acid level ( J:168130 )

• increased levels of asymmetric dimethyl arginine in plasma

abnormal nitric oxide homeostasis ( J:168130 )

• acetylcholine induced stimulation of NO production in isolated aortic rings is attenuated

cardiovascular system

cardiovascular system phenotype ( J:168130 )

N • cardiac structure and function is normal

increased systemic vascular resistance ( J:168130 )

increased left ventricle systolic pressure ( J:168130 )

increased systemic arterial blood pressure ( J:168130 )

increased mean systemic arterial blood pressure ( J:168130 )

increased systemic arterial systolic blood pressure ( J:168130 )

• including aortic systolic pressure

abnormal vascular smooth muscle physiology ( J:168130 )

• isolated aortic ring relaxation is reduced

muscle

abnormal vascular smooth muscle physiology ( J:168130 )

• isolated aortic ring relaxation is reduced