Phenotypes Associated with This Genotype

Genotype
MGI:4882148

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Tg(Ddx4-cre)1Dcas/0
• Genetic Background: involves: 129S4/SvJae * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

enlarged ovary ( J:138697 )

♀ • ovaries are enlarged by P21 due to global primordial follicle activation

abnormal ovary physiology ( J:138697 )

♀ • ovaries explanted at birth and cultured for 8 days grow more rapidly than controls

reproductive system

enlarged ovary ( J:138697 )

♀ • ovaries are enlarged by P21 due to global primordial follicle activation

abnormal ovary physiology ( J:138697 )

♀ • ovaries explanted at birth and cultured for 8 days grow more rapidly than controls

reduced female fertility ( J:138697 )

♀ • females exhibit a dramatic age-dependent decrease in fertility and have no more than two litters

growth/size/body

enlarged ovary ( J:138697 )

♀ • ovaries are enlarged by P21 due to global primordial follicle activation