Analysis Tools
mortality/aging
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• after P17, mice are so severely malformed that they are sacrificed
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limbs/digits/tail
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• cilia on limb mesenchyme are shorted than in wild-type mice
• axoneme doublets are missing in the limb mesenchyme cilia unlike in wild-type mice
• however, length of cilia on the apical ectodermal ridge and ventral ectoderm is normal
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polydactyly
(
J:168038
)
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• severe with 7 to 9 unpatterned digits on each forelimb and a single extra digit on each hindlimb
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syndactyly
(
J:168038
)
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• in 2 of 8 mice
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• at E16.5, the bone collar of the humerus is almost absent unlike in wild-type mice
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short radius
(
J:168038
)
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short ulna
(
J:168038
)
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short femur
(
J:168038
)
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short fibula
(
J:168038
)
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short tibia
(
J:168038
)
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embryo
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• cilia on limb mesenchyme are shorted than in wild-type mice
• axoneme doublets are missing in the limb mesenchyme cilia unlike in wild-type mice
• however, length of cilia on the apical ectodermal ridge and ventral ectoderm is normal
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skeleton
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• at E16.5, the bone collar of the humerus is almost absent unlike in wild-type mice
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• at P0, the central ossified diaphysis is reduced compared to in wild-type mice
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• slightly disorganized
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short radius
(
J:168038
)
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short ulna
(
J:168038
)
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short femur
(
J:168038
)
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short fibula
(
J:168038
)
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short tibia
(
J:168038
)
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• reduced in the limbs at E16.5
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• at E16.5, chondrocyte proliferation in the proximal ulna is decreased compared to in wild-type mice
• hypertrophic chondrocytes exhibit premature differentiation compared to in wild-type mice
• however, levels of chondrocyte apoptosis are normal
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