Phenotypes Associated with This Genotype

Genotype
MGI:4881721

• Allelic Composition: Wls^tm1.1Whsu/Wls^tm1.1Whsu; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal craniofacial morphology ( J:167835 )

• craniofacial abnormalities are detected at E13.5 and E16.5

abnormal neurocranium morphology ( J:167835 )

• severely impaired development

abnormal viscerocranium morphology ( J:167835 )

• severely impaired development

abnormal tooth morphology ( J:167835 )

• tooth defects are detected at E16.5

abnormal craniofacial development ( J:167835 )

• defects in tissues derived from neural crest cells

cleft palate ( J:167835 )

• at E16.5

nervous system

abnormal brain morphology ( J:167835 )

• brain abnormalities manifest at E10.5

abnormal hindbrain development ( J:167835 )

• absence of mid/hindbrain structures at E10.5

abnormal midbrain development ( J:167835 )

• absence of mid/hindbrain structures at E10.5

abnormal midbrain-hindbrain boundary development ( J:167835 )

• expression analysis indicates defects in the establishment of the isthmic organizer activity

absent choroid plexus ( J:167835 )

• at E13.5

absent tectum ( J:167835 )

• at E13.5 and E16.5

absent tegmentum ( J:167835 )

• at E16.5

absent cerebellum ( J:167835 )

• at E13.5 and E16.5

abnormal cranial nerve morphology ( J:167835 )

• fail to form properly

endocrine/exocrine glands

abnormal salivary gland morphology ( J:167835 )

• defects are detected at E16.5

abnormal serous gland morphology ( J:167835 )

• defects are detected at E16.5

digestive/alimentary system

cleft palate ( J:167835 )

• at E16.5

abnormal salivary gland morphology ( J:167835 )

• defects are detected at E16.5

skeleton

abnormal neurocranium morphology ( J:167835 )

• severely impaired development

abnormal viscerocranium morphology ( J:167835 )

• severely impaired development

abnormal tooth morphology ( J:167835 )

• tooth defects are detected at E16.5

growth/size/body

abnormal tooth morphology ( J:167835 )

• tooth defects are detected at E16.5

cleft palate ( J:167835 )

• at E16.5