Phenotypes Associated with This Genotype

Genotype
MGI:4881715

• Allelic Composition: Ackr3^tm1Twb/Ackr3^tm1.1Twb; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber morphology ( J:167833 )

• cellular disarray and enlarged intercellular spaces at 6 months of age

increased myocardial fiber size ( J:167833 )

• at 6 months of age

myocardial fiber disarray ( J:167833 )

cardiac hypertrophy ( J:167833 )

• marked hypertrophy at 6 months of age with much thicker ventricle walls but no change in the size of the ventricular cavity

heart left ventricle hypertrophy ( J:167833 )

• the wall is about 1.4 fold thicker than controls

thick aortic valve ( J:167833 )

• at 6 months of age

• increase in thickness is greater in the aortic valve compared to the pulmonary valve

thick pulmonary valve ( J:167833 )

• at 6 months of age

• increase in thickness is greater in the aortic valve compared to the pulmonary valve

cardiac fibrosis ( J:167833 )

• at 6 months of age

growth/size/body

cardiac hypertrophy ( J:167833 )

• marked hypertrophy at 6 months of age with much thicker ventricle walls but no change in the size of the ventricular cavity

heart left ventricle hypertrophy ( J:167833 )

• the wall is about 1.4 fold thicker than controls

muscle

abnormal myocardial fiber morphology ( J:167833 )

• cellular disarray and enlarged intercellular spaces at 6 months of age

increased myocardial fiber size ( J:167833 )

• at 6 months of age

myocardial fiber disarray ( J:167833 )

heart left ventricle hypertrophy ( J:167833 )

• the wall is about 1.4 fold thicker than controls