Phenotypes Associated with This Genotype

Genotype
MGI:4881525

• Allelic Composition: Tg(YAC46)668Hay/?
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:55405 )

N • no neuronal degeneration is seen at 12 months of age

abnormal long-term potentiation ( J:55405 )

• by 10 months of age, LTP is not induced in CA1 neurons

• glutamate-mediated calcium influx does not occur in CA1 neurons

decreased post-tetanic potentiation ( J:55405 )

• posttetanic potentiation is reduced in 10 month old mutants, indicating impaired presynaptic release

behavior/neurological

behavior/neurological phenotype ( J:55405 )

N • normal motor and behavior function up to 20 months of age