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Phenotypes Associated with This Genotype
Genotype
MGI:4879018
Allelic
Composition
Stat3tm1Xyfu/Stat3tm1.1Xyfu
Tg(Myh6-cre)2182Mds/0
Genetic
Background
involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm1.1Xyfu mutation (0 available); any Stat3 mutation (72 available)
Stat3tm1Xyfu mutation (1 available); any Stat3 mutation (72 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• after 6 months of age
• at 200 days, mice exhibit increased left ventricular chamber size compared with wild-type mice
• mild at 6 months
• severe at 9 months
• after 6 months of age
• doxorubicin-treated mice exhibit a greater decrease in cardiac systolic function compared with similarly treated wild-type mice
• after 6 months of age

immune system
• in the cardiac myocytes of LPS-treated mice
• LPS-treated mice exhibit increased myocyte apoptosis and TNF-alpha levels in cardiac myocytes compared with similarly treated wild-type mice

homeostasis/metabolism
• after 6 months of age
• doxorubicin-treated mice exhibit a greater decrease in cardiac systolic function compared with similarly treated wild-type mice

respiratory system
• after 6 months of age

growth/size/body
• after 6 months of age
• after 6 months of age

muscle
• LPS-treated mice exhibit increased myocyte apoptosis compared with similarly treated wild-type mice

cellular
• LPS-treated mice exhibit increased myocyte apoptosis compared with similarly treated wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/20/2026
MGI 6.24
The Jackson Laboratory