Phenotypes Associated with This Genotype

Genotype
MGI:4878879

• Allelic Composition: Esr1^tm1.2Awo/Esr1^tm1.2Awo; Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:167285 )

♂N • testis weight in adult males is not different from wild-type

absent corpus luteum ( J:167285 )

♀ • in P35 ovaries, corpora lutea are completely absent

♀ • in adult ovaries, few or no corpora lutea are observed

ovary cyst ( J:167285 )

♀ • ovaries from P25 and P35 animals contain numerous cysts

ovarian follicular cyst ( J:167285 )

♀ • adult ovaries also show numerous large follicular cysts

early vaginal opening ( J:167285 )

♀ • observed significantly earlier than in wild-type (13 vs 29 days postnatal)

abnormal estrous cycle ( J:167285 )

♀ • females exhibit prolonged period (weeks or months) of persistent vaginal cornification

♀ • in some animals, isolated "breakthrough" cycles occur followed by more periods of prolonged acyclicity

prolonged diestrus ( J:167285 )

♀ • prolonged period of persistent vaginal cornification is followed by persistent diestrus state

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:167285 )

N • serum luteinizing hormone (LH) levels in adult castrated (cx) males is not different from cx wil-type males; at P35 serum LH levels are similar in mutant and wild-type males

decreased circulating luteinizing hormone level ( J:167285 )

• in absence of ovarian restraint (after ovariectomy), LH secretion is greatly reduced in adult females compared to ovariectomized wild-type females

increased circulating luteinizing hormone level ( J:167285 )

• serum LH concentration is 6-7-fold higher at P15 than in age-matched wild-type; levels remain elevated at P25, then decline to wild-type levels by P35

endocrine/exocrine glands

absent corpus luteum ( J:167285 )

♀ • in P35 ovaries, corpora lutea are completely absent

♀ • in adult ovaries, few or no corpora lutea are observed

ovary cyst ( J:167285 )

♀ • ovaries from P25 and P35 animals contain numerous cysts

ovarian follicular cyst ( J:167285 )

♀ • adult ovaries also show numerous large follicular cysts

growth/size/body

ovary cyst ( J:167285 )

♀ • ovaries from P25 and P35 animals contain numerous cysts

ovarian follicular cyst ( J:167285 )

♀ • adult ovaries also show numerous large follicular cysts