Phenotypes Associated with This Genotype

Genotype
MGI:4868733

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Notch1)Dam}/Gt(ROSA)26Sor⁺; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:167000 )

• mutant bone marrow transplanted chimeras survive to 26 days after pI-pC treatment

neoplasm

increased leukemia incidence ( J:167000 )

• three weeks after pI-pC injection, the bone marrow is almost exclusively composed of CD45.2+eGFP+ DP leukemic cells in the mutant bone marrow transplanted chimeras

• infiltration of the spleens by leukemic DP cells

hematopoietic system

enlarged spleen ( J:167000 )

• severe splenomegaly in mutant bone marrow transplanted chimeras

decreased B cell number ( J:167000 )

• decreased B220+ B cell numbers in mutant bone marrow transplanted chimeras

increased leukocyte cell number ( J:167000 )

• increased WBC counts in mutant bone marrow transplanted chimeras

immune system

enlarged spleen ( J:167000 )

• severe splenomegaly in mutant bone marrow transplanted chimeras

decreased B cell number ( J:167000 )

• decreased B220+ B cell numbers in mutant bone marrow transplanted chimeras

increased leukocyte cell number ( J:167000 )

• increased WBC counts in mutant bone marrow transplanted chimeras

growth/size/body

enlarged spleen ( J:167000 )

• severe splenomegaly in mutant bone marrow transplanted chimeras