Phenotypes Associated with This Genotype

Genotype
MGI:4868447

• Allelic Composition: Col4a3^tm1.1Rkl/Col4a3⁺
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:167404 )

• mice die between 23 and 30 weeks

renal/urinary system

increased urine protein level ( J:167404 )

• at 22 weeks

podocyte foot process effacement ( J:167404 )

• at 22 weeks

abnormal renal glomerulus morphology ( J:167404 )

• at 22 weeks, the glomerular basement membrane exhibits focal thinning and thickening compared to in wild-type mice

glomerulonephritis ( J:167404 )

• beginning at 12 weeks and extensive at 22 weeks

renal interstitial fibrosis ( J:167404 )

• beginning at 12 weeks and extensive at 22 weeks

kidney atrophy ( J:167404 )

• beginning at 12 weeks and extensive at 22 weeks, mice exhibit tubular atrophy unlike wild-type mice

homeostasis/metabolism

increased circulating creatinine level ( J:167404 )

• at 22 weeks

increased urine protein level ( J:167404 )

• at 22 weeks

immune system

glomerulonephritis ( J:167404 )

• beginning at 12 weeks and extensive at 22 weeks