Col4a3^tm1.1Rkl
Targeted Allele Detail

Summary

• Symbol: Col4a3^tm1.1Rkl
• Name: collagen, type IV, alpha 3; targeted mutation 1.1, Raghu Kalluri
• MGI ID: MGI:4868441
• Synonyms: A3mA5h
• Gene: Col4a3 Location: Chr1:82564647-82699778 bp, + strand Genetic Position: Chr1, 42.32 cM
• Alliance: Col4a3^tm1.1Rkl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167404
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The NC1 domain was replaced with the corresponding domain from human Col4a5 and a floxed neo cassette. Cre-mediated recombination removed the neo cassette. (J:167404)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col4a3 Mutation: 60 strains or lines available

References

• Original: J:167404 LeBleu V, et al., Identification of the NC1 domain of {alpha}3 chain as critical for {alpha}3{alpha}4{alpha}5 type IV collagen network assembly. J Biol Chem. 2010 Dec 31;285(53):41874-85
• All: 1 reference(s)