Phenotypes Associated with This Genotype

Genotype
MGI:4868429

• Allelic Composition: Mmp14^tm1Hbh/Mmp14^tm1Hbh; Mmp15^tm1Kohl/Mmp15^tm1Kohl
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:167396 )

• mice die between E10.5 and E11.5

embryo

embryonic growth retardation ( J:167396 )

• at E10.5

decreased embryo size ( J:167396 )

• at E10.5

abnormal placenta labyrinth morphology ( J:167396 )

• establishment of the labyrinthin layer of embryonic and maternal vascular interchange is retarded compared to in wild-type mice

• trophoblasts are present mostly as compact undifferentiated chorionic trophoblasts and far fewer as syncytiotrophoblast compared to in wild-type mice

• at E10.5, mice exhibit disruption of the labyrinth architecture compared with wild-type mice

abnormal placental labyrinth vasculature morphology ( J:167396 )

• the number of fetal vessels extending from the allantoic mesenchyme through the chorionic trophoblasts and into the labyrinth and the degree of branching of fetal vessels are diminished compared to in wild-type mice

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:167396 )

• the number of fetal vessels extending from the allantoic mesenchyme through the chorionic trophoblasts and into the labyrinth and the degree of branching of fetal vessels are diminished compared to in wild-type mice

dilated vasculature ( J:167396 )

• at E10.5

enlarged pericardium ( J:167396 )

• at E10.5

growth/size/body

embryonic growth retardation ( J:167396 )

• at E10.5

decreased embryo size ( J:167396 )

• at E10.5