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Phenotypes Associated with This Genotype
Genotype
MGI:4868398
Allelic
Composition
Flot1tm1.1Arte/Flot1tm1.1Arte
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flot1tm1.1Arte mutation (0 available); any Flot1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• fMLP-treated mice exhibit fewer neutrophils, monocytes, and lymphocytes in the air pouch and cardiac puncture compared to in similarly treated wild-type mice
• fMLP-treated neutrophils exhibit impaired uropod formation compared with similarly treated wild-type cells
• MIP-2 (Cxcl2)-treated neutrophils exhibit impaired chemotaxis into Matrigel compared with similarly treated wild-type cells
• however, fMLP-treated neutrophils exhibit normal chemotax on glass and chemoattractant sensing is normal

homeostasis/metabolism
• MEFs transfected with GFP-APPswe and treated with antiserum to GFP show a slight but significant reduction in antibody uptake
• no colocalization of flotillin1 with APPswe

cellular
• MIP-2 (Cxcl2)-treated neutrophils exhibit impaired chemotaxis into Matrigel compared with similarly treated wild-type cells
• however, fMLP-treated neutrophils exhibit normal chemotax on glass and chemoattractant sensing is normal

nervous system
• MEFs transfected with GFP-APPswe and treated with antiserum to GFP show a slight but significant reduction in antibody uptake
• no colocalization of flotillin1 with APPswe

hematopoietic system
• fMLP-treated mice exhibit fewer neutrophils, monocytes, and lymphocytes in the air pouch and cardiac puncture compared to in similarly treated wild-type mice
• fMLP-treated neutrophils exhibit impaired uropod formation compared with similarly treated wild-type cells
• MIP-2 (Cxcl2)-treated neutrophils exhibit impaired chemotaxis into Matrigel compared with similarly treated wild-type cells
• however, fMLP-treated neutrophils exhibit normal chemotax on glass and chemoattractant sensing is normal


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory