Phenotypes Associated with This Genotype

Genotype
MGI:4867493

• Allelic Composition: Kmt2b^tm1Afst/Kmt2b^tm1.1Afst; Tg(Gdf9-icre)5092Coo/0
• Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal female meiosis I arrest ( J:166778 )

♀ • a small but significant fraction remains arrested in meiosis I in cultured peri-ovulatory oocytes for in vitro oocyte maturation studies

abnormal ovarian follicle number ( J:166778 )

♀ • very few follicles at 36 weeks old

increased primary ovarian follicle number ( J:166778 )

♀ • a higher number of primary growing follicles at 2 weeks old

decreased primordial ovarian follicle number ( J:166778 )

♀ • a 50% decrease in primordial follicles at 3 weeks old

♀ • an 80% reduction in primordial follicles at 8 weeks old

increased secondary ovarian follicle number ( J:166778 )

♀ • increase in growing preantral follicles at 3 weeks old

increased atretic ovarian follicle number ( J:166778 )

♀ • increased number of atretic follicles from 3 week of age onwards

increased follicle recruitment ( J:166778 )

♀ • a higher number of primary growing follicles at 2 weeks old

♀ • a 50% decrease in primordial follicles and an increase in growing preantral follicles at 3 weeks old

♀ • an 80% reduction in primordial follicles at 8 weeks old

♀ • increased number of atretic follicles from 3 week of age onwards

♀ • very few follicles at 36 weeks old

decreased superovulation rate ( J:166778 )

♀ • reduced ovulation rates in 3-week-old superovulated females

♀ • trapped oocytes in luteinizing structures in hormonally stimulated females

female infertility ( J:166778 )

♀

homeostasis/metabolism

decreased circulating estradiol level ( J:166778 )

• decreased serum estradiol levels at 8 weeks old

increased circulating follicle stimulating hormone level ( J:166778 )

• increased serum FSH levels at 8 weeks old

increased circulating luteinizing hormone level ( J:166778 )

• increased serum LH levels at 8 weeks old

cellular

abnormal cell physiology ( J:166778 )

• increased H4K12 acetylation

abnormal female meiosis I arrest ( J:166778 )

♀ • a small but significant fraction remains arrested in meiosis I in cultured peri-ovulatory oocytes for in vitro oocyte maturation studies

abnormal DNA methylation ( J:166778 )

• increased mono-methylated H3K4 in oocytes

• decreased bi- and tri-methylated H3K4 in oocytes

abnormal imprinting ( J:166778 )

• fail to establish transcriptional repression

• 80% of the oocytes are still transcriptionally active at the peri-ovulatory stage

• normal nucleolus configuration

endocrine/exocrine glands

abnormal ovarian follicle number ( J:166778 )

♀ • very few follicles at 36 weeks old

increased primary ovarian follicle number ( J:166778 )

♀ • a higher number of primary growing follicles at 2 weeks old

decreased primordial ovarian follicle number ( J:166778 )

♀ • a 50% decrease in primordial follicles at 3 weeks old

♀ • an 80% reduction in primordial follicles at 8 weeks old

increased secondary ovarian follicle number ( J:166778 )

♀ • increase in growing preantral follicles at 3 weeks old

increased atretic ovarian follicle number ( J:166778 )

♀ • increased number of atretic follicles from 3 week of age onwards

increased follicle recruitment ( J:166778 )

♀ • a higher number of primary growing follicles at 2 weeks old

♀ • a 50% decrease in primordial follicles and an increase in growing preantral follicles at 3 weeks old

♀ • an 80% reduction in primordial follicles at 8 weeks old

♀ • increased number of atretic follicles from 3 week of age onwards

♀ • very few follicles at 36 weeks old