Phenotypes Associated with This Genotype

Genotype
MGI:4867008

• Allelic Composition: Jag1^tm2Grid/Jag1^tm2Grid; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:166769 )

• die at approximately E10.5

cardiovascular system

abnormal vascular smooth muscle morphology ( J:166769 )

• non-cell autonomous defects in vascular smooth muscle cell differentiation

pericardial edema ( J:166769 )

hemorrhage ( J:166769 )

embryo

abnormal vitelline vascular remodeling ( J:166769 )

• fail to remodel the primary vascular plexus of the yolk sac to form large blood vessels

homeostasis/metabolism

pericardial edema ( J:166769 )

muscle

abnormal vascular smooth muscle morphology ( J:166769 )

• non-cell autonomous defects in vascular smooth muscle cell differentiation