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Phenotypes Associated with This Genotype
Genotype
MGI:4850098
Allelic
Composition		 Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Pik3cdtm2.1Tnr mutation (0 available); any Pik3cd mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:164283 )
N
• mice exhibit normal germinal center B cell numbers, NP-specific IgG1 titers, and immune memory response after immunization
increased IgE level ( J:164283 )
• after NP-CGG immunization, antigen-specific IgE titers are increased 30-fold compared to in similarly treated wild-type mice

hematopoietic system
increased IgE level ( J:164283 )
• after NP-CGG immunization, antigen-specific IgE titers are increased 30-fold compared to in similarly treated wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory